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modafinil will improve the stage or impact of clobazam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Dosage adjustment may be necessary; CYP2C19 inhibitors may well cause greater publicity to N-desmethylclobazam (Lively metabolite).modafinil will reduce the level or effect of fruquintinib by impacting hepatic/intestinal enzym